Our mission

Mission of this society is to promote health benefits of phytonutrients.

Isothiocyanate
   Isothiocyanates are derived from the breakdown of glucosinolates – sulfur-containing compounds found in cruciferous vegetables such as broccoli, cabbage and kale. Research on isothiocyanates has shown them to be protective of DNA, to inhibit cell proliferation and to stop the progression of some tumors.1 Several epidemiological studies have reported an inverse association between consumption of dietary isothiocyanates and cancer risk in several organs.2-5 Among genetically susceptible individuals, low intakes of cruciferous vegetables may be associated with higher kidney cancer risks in particular.6 The PI for isothiocyanate was found to be 1.7 mg/day. Among adults 19 years and older, 18% meet this PI, which means 82% fall short. It has been shown that the percentage of Americans, by age group, who has a gap in their isothiocyanate consumption.

1. Fimognari C, Hrelia P. Sulforaphane as a promising molecule for fighting cancer. Mutat Res 2007;635:90-104.
2. Spitz MR, Duphorne CM, Detry MA, et al. Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomark Prev 2000;9:1017-20.
3. Zhao B, Seow A, Lee EJ, et al. Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol Biomark Prev 20 01;10:1063-7.
4. Seow A, Yuan JM, Sun CL, Van Den Berg D, Lee HP, Yu MC. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carci nogenesis 2002;23:2055-61.
5. Fowke JH, Chung FL, Jin F, et al. Urinary isothiocyanate levels, Brassica, and human breast cancer. Cancer Res 2003;63:3980-86.
6. Moore LE, Brennan P, Karami S, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis 2007;28:1960-4.